Mercury preparation for therapeutic purposes.



ous solution.

Winnie smarts PATENT @FFTGE.

HANS BUCHTALA, 0F GRA'IZ, AUSTRIA-HUNGARY, ASSIGNOR TO DR. BAYER ESTABSA, A FIRM COMPRISING DR. DEZSO BAYER AND RUDOLPH BRAUN DE BEL-ATIN,0F

BUDAPEST, AUSTRIA-HUNGARY.

MERCURY PREPARATION FOR THERAPEUTIC PURPOSES.

Specification of Letters Patent.

Patented Jan. 11, 191%.

Ito Drawing. Original application filed June 5, 1913, Serial No.771,796. Divided and this application filed M55723, 1914.

To all whom it may concern Be it known that I, HANs BUOI-ITALA, asubject of the Emperor of Austria-Hungary, residing in Gratz,Austria-Hungary have invented a certain new and useful MercuryPreparation for Therapeutic Purposes, of which the following is aspecification.

The object of this invention is to provide a therapeutic'mercurial,preparation characterized by the uniformity and stability of itsalkaline solutions, and one which in its application is free fromirritation and smarting.

The present improvement provides a mercury-tyrosin compound, whichbrings out fully the therapeutic mercurial effects while at the sametime there is repressed or avoided as far as possible an effectinjurious to the bodily health. By heating a solution of tyrosin (B-parahydroxyphenyl-oz-aminopropionic acid) in water with freshlyprecipitated mercuric oxid until the color of the mercuric oxiddisappears, there arises a milky liquid out of which there separates awhite precipitate. The same precipitate is obtained by boiling theaqueous tyrosin solution in the presence of mercuric salts of weakacids, such as for example, mercuric acetate, which are hydrolyzed inhot aque- In this case a bivalent mercury ion may be split off whichenters directly into reaction with the tyrosin.

Ezmmples.

' grams of mercurial acetate dissolved in water are added, and thesolution is heated for two to two and a half hours on the water bath.

After the cooling the centrifugal drying machine is employed, theprecipitate is washed with water and dried in the drying Serial No.840,454.

'meters of water, with the addition of 1.05

cubic centimeters of 1% soda lye or with the addition of 2 cubiccentimeters of 1% potash lye, a clear stable solution.

The body itself, as well as its alkaline solutions are not darkened bysulfid of hydrogen. In cold dilute mineral acids the body is insoluble;on heating the same with mineral acid there is obtained in consequenceof the opening up of the tyrosin a solution from which the mercury isseparated off by means of sulfureted hydrogen as a sulfid.

In organic solvents, such as, alcohol, glycerin, benzol, ether,chloroform, bisulfid of carbon, as well as in organic acid, such asacetic acid, furthermore, in fats and oils, the body is insoluble, onthe other hand it is soluble in small quantities and under continuousboiling in aqueous solutions of tartaric acid.

The alkaline solutions on concentration of something over 1% show aquality in a short time of becoming viscous and finally of stiffeninglike colloids. If, in a vacuum over concentrated sulfuric acid the watercontent is partially removed from the alkaline solutions, there isattained a colloidal body which is not clearly soluble in water. If inthe same manner the entire water content is removed from the alkalinesolution, then there is obtained a pulverulent body which is insolublein water. The same thing takes place if the alkaline solution is mixedwith so much alcohol that a precipitate takes place. If the alkalinesolutions of the new mercurial compound are neutralized with mineralacids or acetic acid, then there tions with amin acids, glycocol, alaminand asparagin while characterized by the fact that their solutions donot precipitate albumen, still these preparations have not found greaterpractical use for the reason that their solutions very easily andrapidly de-- compose. The mercurial combination of tyrosin obtained inaccordance with the present invention is pre'minently adapted fortherapeutic purposes owing to the stability of its alkali solution.These qualities which distinguish the substance obtained according tothe present process are dependent upon its basically novel composition.The assumption is, as a mater of fact justified, that the two valancesof the mercury replace the hydrogen on the one hand of the hydroxylgroup in the benzol nucleus, on the other hand replace the hydrogen ofthe amin group in the side chain.

Introduced into the organism in different manners both internally andalso intramuscularly as well as especially intravenous'ly,in

Lineman .smarting or astringent effect.

I claim as my invention 1. An alkaline solution of a stable compound oftyrosin and mercury for therapeutic use, said mercury compound havingthe empirical formula C H O NHg.

2. An alkaline solution of a stable compound of tyrosin and mercury fortherapeutic use, said mercury compound being'obtained by heating asolution of tyrosin and a mercuric compound, as the oxid or a salt of aweak acid, the negative element or radical of which does not enter intothe compound.

In witness whereof, I have hereunto signed my name in the presenceof-two subscribing witnesses.

HANS BUCHTALA.

Witnesses:

AUGUST Fnccnn, ADA MARIA BERGER.

